Lipid Coating

Enhanced permeability and stability through lipid surface modification

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  • Lipid Coating

Lipid Coating

Lipid nanoparticles (LNPs) can be surface-coated with polymers or enzymes to dramatically enhance
mucosal permeability and bioavailability.
This technology enables stable delivery even under digestive enzyme activity and pH fluctuations,
making it ideal for functional food applications and pharmaceutical nano-delivery systems.

Lipid coating structure

  • Increased Mucoadhesion

    Mucoadhesion improvement
    Surface modification enhances mucosal adhesion
    and permeability compared to unmodified lipid nanoparticles

  • Prolonged Retention

    Sustained release
    Controlled and prolonged release of active
    compounds through surface-modified nanoparticles

  • Enhanced Stability In Vivo

    Enhanced stability in vivo
    Improved stability against first-pass metabolism
    and other physiological degradation mechanisms

Related Publications

No Title
1 Bromelain-decorated nanoscale liposomes for mucus permeation and intestinal absorption in oral drug delivery (ACS Appl. Nano Mater., 2023, 7(1): 348–357)
2 Precise control of liposome size based on solvent type and membrane properties (Langmuir, 2023)
3 Controlled-rate slow freezing with lyoprotective agents to retain lipid nanovesicle integrity during lyophilization (Sci. Rep., 2021, 11: 24354)
4 Characterization of phospholipid vesicles prepared in CO₂/water systems at high pressure (ACS Appl. Mater. Interfaces, 2017, 9(49): 42761–42771)
5 Method for preparing liposome frozen powder capable of retaining bilayer structure efficiently (US Patent: US10660853B2)